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Vikings vs 49ers Prediction, Picks, Best Bets & Parlay

Free NFL prediction and picks for Sunday, November 22, 2026 · powered by DataStreak

AWAY

Minnesota Vikings

6-2 · L2

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San Francisco 49ers

7-1 · W1

Vikings vs 49ers Prediction

Vikings vs 49ers on the slate. The angles below are where the value sits.

The matchup data is what it is. The prop board is where the actual market inefficiency hides.

Vikings vs 49ers Picks

Books have not posted player props for MIN at SF yet. Lines usually go up a few hours before first pitch or tip-off; check back closer to game time. See all of today’s free picks across the slate.

Injury Report

37 listed

JUST IN: Donovan Jackson out → IR · Nick Samac out → IR · Demond Claiborne out → IR · Josh Oliver out → IR · Kyler Murray doubtful → Out (Hamstring) · Jordan Addison questionable → Out (Thumb) · Jauan Jennings questionable → Out (Calf) · Blake Cashman questionable → Out (Concussion) · Tyrion Ingram-Dawkins questionable → Out (Ankle) · Max Brosmer inactive → Out (Coach's Decision) · T.J. Hockenson questionable → Out (Wrist) · Jeshaun Jones reserve-sus → Questionable (Shoulder) · Christian Kirk out → IR · Nate Hobbs ir-r → Injured Reserve (Groin) · Jake Tonges questionable → IR · Sam Okuayinonu questionable → IR · Isaac Guerendo pup-p → PUP R · Ricky Pearsall injured-reserve → IR · C.J. West ir → Injured Reserve (Knee) · Nick Martin active → IR · Darrick Forrest injured-reserve → IR · De'Zhaun Stribling out → IR · Gracen Halton ir → Injured Reserve (Ankle) · Alfred Collins out → IR · Mike Evans questionable → Out (Achilles) · Tatum Bethune inactive → Out (Coach's Decision) · Kurtis Rourke inactive → Out (Coach's Decision) · Enrique Cruz Jr. inactive → Out (Coach's Decision) · Trent Williams active → Questionable (Shoulder) · Brett Toth ir → Questionable

MIN

Donovan Jackson
Since Oct 4
IR
Nick Samac
Since Sep 13
IR
Demond Claiborne
Since Nov 5
IR
Josh Oliver
Since Sep 27
IR
Jamal Adams
Since Aug 19
IR
Tyler Batty
Since Aug 30
IR
Kyler Murray
Hamstring·Since Nov 9
Out
Jordan Addison
Thumb·Since Nov 12
Out
Jauan Jennings
Calf·Since Nov 4
Out
Blake Cashman
Concussion·Since Nov 10
Out
Tyrion Ingram-Dawkins
Ankle·Since Nov 9
Out
Max Brosmer
Coach's Decision·Since Nov 14
Out
T.J. Hockenson
Wrist·Since Nov 10
Out
Jeshaun Jones
Shoulder·Since Nov 14
Questionable
Bo Richter
Foot·Since Nov 14
Questionable

Christian Kirk
Since Nov 4
IR
Nate Hobbs
Groin·Since Aug 14
Injured Reserve
Jake Tonges
Since Sep 10
IR
Sam Okuayinonu
Since Sep 4
IR
Isaac Guerendo
Since Aug 6
PUP R
Ricky Pearsall
Since Aug 6
IR
C.J. West
Knee·Since Sep 23
Injured Reserve
Nick Martin
Since Sep 1
IR
Darrick Forrest
Since May 27
IR
De'Zhaun Stribling
Since Sep 10
IR
Gracen Halton
Ankle·Since Nov 7
Injured Reserve
Alfred Collins
Since Sep 7
IR
Nick Zakelj
Since Aug 31
IR
Mikail Kamara
Since Aug 3
IR
Mike Evans
Achilles·Since Oct 19
Out
Tatum Bethune
Coach's Decision·Since Sep 9
Out
Kurtis Rourke
Coach's Decision·Since Sep 9
Out
Enrique Cruz Jr.
Coach's Decision·Since Sep 9
Out
Brandin Cooks
Coach's Decision·Since Nov 14
Out
Austen Pleasants
Since Aug 31
IR R
Trent Williams
Shoulder·Since Nov 11
Questionable
Brett Toth
Since Aug 6
Questionable

Team Trends

Visit DataStreak for full details

Head-to-Head

MIN 3-2 over SF (2-0 ATS)

Date	Matchup	Score	Winner
2024-09-15	SF @ MIN	17–23	MIN
2023-10-24	SF @ MIN	17–22	MIN
2021-11-28	MIN @ SF	26–34	SF
2020-01-11	MIN @ SF	10–27	SF
2018-09-09	SF @ MIN	16–24	MIN

Picks, parlays, injuries, trends, and matchup context powered byDataStreak

The Final Word

The plays are above. The math is in the streaks. The picks were free, the analysis is free, and tomorrow's badge will tell you the rest.

Vikings vs 49ers FAQ

Where can I find free Vikings vs 49ers picks for Sunday, November 22, 2026?

Today's algorithmic plays didn't include Vikings vs 49ers, but our full free NFL picks page covers every matchup that did clear the quality bar.

What's the prediction for Vikings vs 49ers?

Our prediction is built from team form (records, recent results, win/loss streaks), live moneyline and spread odds across major US books, and DataStreak's algorithmic player-prop research. Every claim on this page is data-backed — no hot takes.

Are these Vikings vs 49ers best bets really free?

Yes. Every prediction, pick, and parlay on this page is free, no signup, no paywall.

How is The Cover different from Covers, ATS, or pay-for-pick services?

Three things. (1) Free, full stop — every page, every day. (2) Picks are algorithmic with transparent quality bars (8+ game streak, 75%+ hit rate over 20 games), not opinion columns. (3) Modern UX: live odds, push notifications, comments, mobile-first PWA install.