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Cardinals vs 49ers Prediction, Picks, Best Bets & Parlay

Free NFL prediction and picks for Sunday, September 27, 2026 · powered by DataStreak

AWAY

Arizona Cardinals

1-1 · L1

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San Francisco 49ers

2-0 · W2

Cardinals vs 49ers Prediction

Cardinals vs 49ers on the slate. The angles below are where the value sits.

Two teams, one slate of props, and a model that's been right more than it's been wrong. The plays below earned their spot.

Cardinals vs 49ers Picks

Books have not posted player props for ARI at SF yet. Lines usually go up a few hours before first pitch or tip-off; check back closer to game time. See all of today’s free picks across the slate.

Injury Report

55 listed

JUST IN: Tip Reiman pup-p → PUP R · Jameson Geers active → IR · Kitan Crawford ir → Injured Reserve (Ankle) · Chase Bisontis out → IR · Joey Blount questionable → IR · Trey Benson questionable → IR · Kaleb Proctor questionable → IR · James Conner questionable → IR R · Zachary Carter questionable → IR R · Garrett Williams inactive → Out (Achilles) · Josh Fryar inactive → Out (Coach's Decision) · Reggie Virgil inactive → Out (Coach's Decision) · Andrew Billings inactive → Out (Knee) · Carson Beck inactive → Out (Coach's Decision) · Isaiah Adams inactive → Questionable · Jack Gibbens active → Questionable · Dadrion Taylor-Demerson inactive → Questionable · Brandon Aiyuk out → Reserve DNR (Personal) · Jake Tonges ir → Injured Reserve (Knee - MCL) · Isaac Guerendo pup-p → PUP R · Nick Martin active → IR · Ricky Pearsall injured-reserve → IR · Darrick Forrest injured-reserve → IR · De'Zhaun Stribling ir → Injured Reserve (Ankle) · Mykel Williams pup-p → PUP R · Alfred Collins out → IR · Nate Hobbs questionable → IR · Sam Okuayinonu questionable → IR · Brett Toth questionable → IR · Demarcus Robinson out → Doubtful (Ankle) · Tatum Bethune inactive → Out (Coach's Decision) · Kurtis Rourke inactive → Out (Coach's Decision) · Jordan James questionable → Inactive · Jordan Watkins inactive → Out (Coach's Decision) · Enrique Cruz Jr. inactive → Out (Coach's Decision) · James Thompson Jr. questionable → Doubtful (Ankle) · Ephesians Prysock inactive → Out (Coach's Decision) · Christian Kirk questionable → IR R · George Kittle pup-p → Questionable · Jack Jones active → Questionable (Foot) · Kaelon Black active → Questionable · Romello Height active → Questionable · Mike Evans active → Questionable (Hip)

ARI

Tip Reiman
Since Aug 6
PUP R
Jameson Geers
Since Sep 7
IR
Kitan Crawford
Ankle·Since Sep 15
Injured Reserve
Chase Bisontis
Since Aug 13
IR
Joey Blount
Since Aug 8
IR
Trey Benson
Since Aug 15
IR
Kaleb Proctor
Since Aug 11
IR
James Conner
Since Aug 15
IR R
Zachary Carter
Since Aug 7
IR R
Garrett Williams
Achilles·Since Sep 9
Out
Josh Fryar
Coach's Decision·Since Sep 19
Out
Reggie Virgil
Coach's Decision·Since Sep 13
Out
Andrew Billings
Knee·Since Sep 13
Out
Carson Beck
Coach's Decision·Since Sep 13
Out
Isaiah Adams
Since Sep 9
Questionable
Jack Gibbens
Since Sep 20
Questionable
Dadrion Taylor-Demerson
Since Aug 22
Questionable
Roy Lopez
Since Sep 20
Questionable
Cody Simon
Since Sep 20
Questionable
Isaac Seumalo
Since Sep 16
Questionable
Max Melton
Toe·Since Sep 20
Questionable
Will Johnson
Neck·Since Sep 20
Questionable

Brandon Aiyuk
Personal·Since Feb 28
Reserve DNR
Jake Tonges
Knee - MCL·Since Sep 10
Injured Reserve
Isaac Guerendo
Since Aug 6
PUP R
Nick Martin
Since Sep 1
IR
Ricky Pearsall
Since Aug 6
IR
Darrick Forrest
Since May 27
IR
De'Zhaun Stribling
Ankle·Since Sep 10
Injured Reserve
Mykel Williams
Since Aug 6
PUP R
Alfred Collins
Since Sep 7
IR
Nate Hobbs
Since Aug 14
IR
Sam Okuayinonu
Since Sep 4
IR
Brett Toth
Since Aug 6
IR
Mikail Kamara
Since Aug 11
IR
Nick Zakelj
Since Aug 31
IR
Demarcus Robinson
Ankle·Since Sep 20
Doubtful
Tatum Bethune
Coach's Decision·Since Sep 10
Out
Kurtis Rourke
Coach's Decision·Since Sep 10
Out
Jordan James
Since Sep 20
Inactive
Jordan Watkins
Coach's Decision·Since Sep 10
Out
Enrique Cruz Jr.
Coach's Decision·Since Sep 10
Out
James Thompson Jr.
Ankle·Since Sep 20
Doubtful
Ephesians Prysock
Coach's Decision·Since Sep 10
Out
Christian Kirk
Since Aug 13
IR R
Austen Pleasants
Since Aug 31
IR R
George Kittle
Since Sep 20
Questionable
Jack Jones
Foot·Since Sep 20
Questionable
Kaelon Black
Since Sep 20
Questionable
Romello Height
Since Sep 20
Questionable
Mike Evans
Hip·Since Sep 20
Questionable
Kyle Juszczyk
Since Sep 20
Questionable
Khalid Kareem
Since Sep 20
Questionable
Eddy Pineiro
Since Sep 20
Questionable
Keion White
Since Sep 20
Questionable

Team Trends

Visit DataStreak for full details

Head-to-Head

SF 3-2 over ARI (2-3 ATS)

Date	Matchup	Score	Winner
2025-11-16	SF @ ARI	41–22	SF
2025-09-21	ARI @ SF	15–16	SF
2025-01-05	SF @ ARI	24–47	ARI
2024-10-06	ARI @ SF	24–23	ARI
2023-12-17	SF @ ARI	45–29	SF

Picks, parlays, injuries, trends, and matchup context powered byDataStreak

The Final Word

Numbers in, narrative out. The plays speak for themselves.

Cardinals vs 49ers FAQ

Where can I find free Cardinals vs 49ers picks for Sunday, September 27, 2026?

Today's algorithmic plays didn't include Cardinals vs 49ers, but our full free NFL picks page covers every matchup that did clear the quality bar.

What's the prediction for Cardinals vs 49ers?

Our prediction is built from team form (records, recent results, win/loss streaks), live moneyline and spread odds across major US books, and DataStreak's algorithmic player-prop research. Every claim on this page is data-backed — no hot takes.

Are these Cardinals vs 49ers best bets really free?

Yes. Every prediction, pick, and parlay on this page is free, no signup, no paywall.

How is The Cover different from Covers, ATS, or pay-for-pick services?

Three things. (1) Free, full stop — every page, every day. (2) Picks are algorithmic with transparent quality bars (8+ game streak, 75%+ hit rate over 20 games), not opinion columns. (3) Modern UX: live odds, push notifications, comments, mobile-first PWA install.