Preview·4:25 PM EDT·Levi's Stadium

Broncos vs 49ers Prediction, Picks, Best Bets & Parlay

Free NFL prediction and picks for Sunday, October 4, 2026 · powered by DataStreak

AWAY

Denver Broncos

1-1 · W1

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San Francisco 49ers

2-0 · W2

Broncos vs 49ers Prediction

Broncos vs 49ers on the slate. The angles below are where the value sits.

Records and recent form set the table. The props are where the meal gets served.

Broncos vs 49ers Best Bets

Live odds across FanDuel, Caesars, and Bovada. Broncos vs 49ers moneyline, spread, and current price movement.

via FanDuel

	ML	SP
Broncos	+124	+3 -120
49ers	-146	-3 -102

Broncos vs 49ers Picks

Books have not posted player props for DEN at SF yet. Lines usually go up a few hours before first pitch or tip-off; check back closer to game time. See all of today’s free picks across the slate.

Injury Report

39 listed

JUST IN: Nick Gargiulo pup-p → PUP R (Knee - ACL) · Jonah Coleman ir → Injured Reserve (Ankle) · Michael Deiter out → IR · Levelle Bailey questionable → IR · Jonathon Cooper active → Out (Personal) · Caleb Lohner questionable → IR R · Marvin Mims Jr. inactive → Questionable (Foot) · RJ Harvey inactive → Questionable · J.K. Dobbins active → Questionable · Brandon Aiyuk out → Reserve DNR (Personal) · Demarcus Robinson ir → Injured Reserve (Ankle) · Jake Tonges questionable → IR · Isaac Guerendo pup-p → PUP R · Ricky Pearsall injured-reserve → IR · Brett Toth questionable → IR · Mykel Williams pup-p → PUP R · C.J. West ir → Injured Reserve (Undisclosed) · De'Zhaun Stribling out → IR · Sam Okuayinonu questionable → IR · Alfred Collins out → IR · Nick Martin active → IR · Nate Hobbs questionable → IR · Darrick Forrest injured-reserve → IR · Tatum Bethune questionable → Inactive · Kurtis Rourke questionable → Inactive · Nick Bosa doubtful → Out (Calf) · Enrique Cruz Jr. active → Inactive · Romello Height questionable → Out (Hand) · Christian Kirk questionable → IR R · James Thompson Jr. doubtful → Out (Ankle) · Ephesians Prysock questionable → Inactive · Mike Evans active → Questionable (Hip) · Jack Jones active → Questionable (Foot)

DEN

Nick Gargiulo
Knee - ACL·Since Feb 28
PUP R
Jonah Coleman
Ankle·Since Sep 22
Injured Reserve
Michael Deiter
Since Aug 11
IR
Levelle Bailey
Since Aug 15
IR
Jonathon Cooper
Personal·Since Aug 30
Out
Caleb Lohner
Since Aug 3
IR R
Sam Ehlinger
Since Sep 14
Inactive
Frank Crum
Since Aug 31
IR R
Marvin Mims Jr.
Foot·Since Sep 25
Questionable
RJ Harvey
Since Sep 16
Questionable
J.K. Dobbins
Since Sep 23
Questionable

Brandon Aiyuk
Personal·Since Feb 28
Reserve DNR
Demarcus Robinson
Ankle·Since Sep 20
Injured Reserve
Jake Tonges
Since Sep 10
IR
Isaac Guerendo
Since Aug 6
PUP R
Ricky Pearsall
Since Aug 6
IR
Brett Toth
Since Aug 6
IR
Mykel Williams
Since Aug 6
PUP R
C.J. West
Undisclosed·Since Sep 22
Injured Reserve
De'Zhaun Stribling
Since Sep 10
IR
Sam Okuayinonu
Since Sep 4
IR
Alfred Collins
Since Sep 7
IR
Nick Martin
Since Sep 1
IR
Nate Hobbs
Since Aug 14
IR
Darrick Forrest
Since May 27
IR
Mikail Kamara
Since Aug 11
IR
Nick Zakelj
Since Aug 31
IR
Tatum Bethune
Since Sep 10
Inactive
Kurtis Rourke
Since Sep 10
Inactive
Nick Bosa
Calf·Since Sep 23
Out
Enrique Cruz Jr.
Since Sep 10
Inactive
Romello Height
Hand·Since Sep 24
Out
Christian Kirk
Since Aug 13
IR R
James Thompson Jr.
Ankle·Since Sep 20
Out
Ephesians Prysock
Since Sep 10
Inactive
Austen Pleasants
Since Aug 31
IR R
Jordan Watkins
Since Sep 10
Inactive
Mike Evans
Hip·Since Sep 24
Questionable
Jack Jones
Foot·Since Sep 20
Questionable

Team Trends

Visit DataStreak for full details

Head-to-Head

SF 3-2 over DEN (0-1 ATS)

Date	Matchup	Score	Winner
2022-09-26	SF @ DEN	10–11	DEN
2018-12-09	DEN @ SF	14–20	SF
2014-10-20	SF @ DEN	17–42	DEN
2010-10-31	DEN @ SF	16–24	SF
2006-12-31	SF @ DEN	26–23	SF

Picks, parlays, injuries, trends, and matchup context powered byDataStreak

The Final Word

Some games you watch for the result. Some you watch for the props. Tonight is both.

Broncos vs 49ers FAQ

Where can I find free Broncos vs 49ers picks for Sunday, October 4, 2026?

Today's algorithmic plays didn't include Broncos vs 49ers, but our full free NFL picks page covers every matchup that did clear the quality bar.

What's the prediction for Broncos vs 49ers?

Our prediction is built from team form (records, recent results, win/loss streaks), live moneyline and spread odds across major US books, and DataStreak's algorithmic player-prop research. Every claim on this page is data-backed — no hot takes.

Are these Broncos vs 49ers best bets really free?

Yes. Every prediction, pick, and parlay on this page is free, no signup, no paywall.

How is The Cover different from Covers, ATS, or pay-for-pick services?

Three things. (1) Free, full stop — every page, every day. (2) Picks are algorithmic with transparent quality bars (8+ game streak, 75%+ hit rate over 20 games), not opinion columns. (3) Modern UX: live odds, push notifications, comments, mobile-first PWA install.