Preview·4:25 PM EDT·Lumen Field

49ers vs Seahawks Prediction, Picks, Best Bets & Parlay

Free NFL prediction and picks for Sunday, October 11, 2026 · powered by DataStreak

AWAY

San Francisco 49ers

3-0 · W3

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Seattle Seahawks

2-1 · L1

49ers vs Seahawks Prediction

Seahawks as a heavy favorite means the moneyline is dead money. Pivot to the prop board — that's where the edge lives tonight.

The matchup data is what it is. The prop board is where the actual market inefficiency hides.

49ers vs Seahawks Best Bets

Live odds across FanDuel, Caesars, and Bovada. 49ers vs Seahawks moneyline, spread, and current price movement.

via FanDuel

	ML	SP
49ers	+168	+3.5 -105
Seahawks	-200	-3.5 -115

49ers vs Seahawks Picks

Books have not posted player props for SF at SEA yet. Lines usually go up a few hours before first pitch or tip-off; check back closer to game time. See all of today’s free picks across the slate.

Injury Report

54 listed

JUST IN: Isaac Guerendo pup-p → PUP R · De'Zhaun Stribling out → IR · Demarcus Robinson out → IR · Christian Kirk ir-r → Injured Reserve (Calf) · Brandon Aiyuk out → Reserve DNR · Nate Hobbs questionable → IR · Jake Tonges questionable → IR · Sam Okuayinonu questionable → IR · Mykel Williams pup-p → PUP R (Knee - ACL) · Alfred Collins out → IR · Darrick Forrest injured-reserve → IR · Nick Martin active → IR · Brett Toth questionable → IR · Ricky Pearsall injured-reserve → IR · Tatum Bethune questionable → Inactive · Nick Bosa doubtful → Out (Calf) · Kurtis Rourke questionable → Inactive · Enrique Cruz Jr. active → Inactive · James Thompson Jr. questionable → Out (Ankle) · Ephesians Prysock questionable → Inactive · Romello Height inactive → Questionable · Mike Evans out → Questionable (Ribs) · Gracen Halton active → Questionable · Jaden Dugger active → Questionable (Shoulder) · Trent Williams active → Questionable · Zach Charbonnet pup-p → PUP R (Knee - ACL) · Jake Bobo questionable → IR · Anthony Bradford questionable → IR · Robbie Ouzts active → IR · Jadarian Price ir → Injured Reserve (Chest) · Bud Clark active → IR · Mason Richman out → IR · Jalen Milroe out → Inactive · Nick Kallerup out → Inactive · Beau Stephens active → Inactive · Irvin Charles active → IR R · Chazz Surratt active → Questionable (Calf) · Julian Love inactive → Questionable · Ty Okada inactive → Questionable (Hamstring) · Brandon Pili inactive → Questionable · George Holani active → Questionable

Isaac Guerendo
Since Aug 6
PUP R
De'Zhaun Stribling
Since Sep 10
IR
Demarcus Robinson
Since Sep 20
IR
Christian Kirk
Calf·Since Aug 13
Injured Reserve
Brandon Aiyuk
Since Feb 28
Reserve DNR
Nate Hobbs
Since Aug 14
IR
Jake Tonges
Since Sep 10
IR
Sam Okuayinonu
Since Sep 4
IR
Mykel Williams
Knee - ACL·Since Aug 6
PUP R
Alfred Collins
Since Sep 7
IR
Darrick Forrest
Since May 27
IR
Nick Martin
Since Sep 1
IR
Brett Toth
Since Aug 6
IR
Ricky Pearsall
Since Aug 6
IR
C.J. West
Since Sep 23
IR
Nick Zakelj
Since Aug 31
IR
Mikail Kamara
Since Aug 11
IR
Tatum Bethune
Since Sep 10
Inactive
Nick Bosa
Calf·Since Sep 23
Out
Kurtis Rourke
Since Sep 10
Inactive
Enrique Cruz Jr.
Since Sep 10
Inactive
James Thompson Jr.
Ankle·Since Sep 27
Out
Ephesians Prysock
Since Sep 10
Inactive
Austen Pleasants
Since Aug 31
IR R
Romello Height
Since Sep 28
Questionable
Mike Evans
Ribs·Since Oct 1
Questionable
Gracen Halton
Since Sep 27
Questionable
Jaden Dugger
Shoulder·Since Oct 1
Questionable
Trent Williams
Since Sep 27
Questionable
Dre Greenlaw
Quadriceps·Since Oct 2
Questionable
Keion White
Hamstring·Since Sep 29
Questionable

SEA

Zach Charbonnet
Knee - ACL·Since Jul 22
PUP R
Jake Bobo
Since Sep 7
IR
Anthony Bradford
Since Sep 16
IR
Robbie Ouzts
Since Aug 11
IR
Jadarian Price
Chest·Since Sep 29
Injured Reserve
Bud Clark
Since Aug 25
IR
Mason Richman
Since Feb 28
IR
Jalen Milroe
Since Feb 28
Inactive
Nick Kallerup
Since Feb 28
Inactive
Beau Stephens
Since Sep 9
Inactive
Irvin Charles
Since Aug 31
IR R
Montorie Foster Jr.
Since Sep 20
Inactive
Avery Smith
Since Sep 27
Inactive
Connor O'Toole
Since Sep 20
Inactive
Mike Morris
Since Sep 9
Inactive
Chazz Surratt
Calf·Since Oct 1
Questionable
Julian Love
Since Sep 24
Questionable
Ty Okada
Hamstring·Since Sep 6
Questionable
Brandon Pili
Since Sep 20
Questionable
George Holani
Since Sep 30
Questionable
Jarran Reed
Since Sep 30
Questionable
Josh Jones
Since Sep 16
Questionable
Grey Zabel
Since Sep 30
Questionable

Team Trends

Visit DataStreak for full details

Head-to-Head

SEA 3-2 over SF (3-2 ATS)

Date	Matchup	Score	Winner
2026-01-18	SF @ SEA	6–41	SEA
2026-01-04	SEA @ SF	13–3	SEA
2025-09-07	SF @ SEA	17–13	SF
2024-11-17	SEA @ SF	20–17	SEA
2024-10-11	SF @ SEA	36–24	SF

Picks, parlays, injuries, trends, and matchup context powered byDataStreak

The Final Word

Big favorites usually win. Big favorites also usually leave value on the prop board because the books spend all their attention on the moneyline. We took advantage.

49ers vs Seahawks FAQ

Where can I find free 49ers vs Seahawks picks for Sunday, October 11, 2026?

Today's algorithmic plays didn't include 49ers vs Seahawks, but our full free NFL picks page covers every matchup that did clear the quality bar.

What's the prediction for 49ers vs Seahawks?

Our prediction is built from team form (records, recent results, win/loss streaks), live moneyline and spread odds across major US books, and DataStreak's algorithmic player-prop research. Every claim on this page is data-backed — no hot takes.

Are these 49ers vs Seahawks best bets really free?

Yes. Every prediction, pick, and parlay on this page is free, no signup, no paywall.

How is The Cover different from Covers, ATS, or pay-for-pick services?

Three things. (1) Free, full stop — every page, every day. (2) Picks are algorithmic with transparent quality bars (8+ game streak, 75%+ hit rate over 20 games), not opinion columns. (3) Modern UX: live odds, push notifications, comments, mobile-first PWA install.