Preview·6:40 PM EDT·PNC Park

Cardinals vs Pirates Prediction, Picks, Best Bets & Parlay

Free MLB prediction and picks for Tuesday, September 22, 2026 · powered by DataStreak

AWAY

St. Louis Cardinals

75-76 · W2

HOME

Pittsburgh Pirates

75-75 · W1

Cardinals vs Pirates Prediction

Cardinals vs Pirates on the slate. The angles below are where the value sits.

Records and recent form set the table. The props are where the meal gets served.

Cardinals vs Pirates Picks

Books have not posted player props for STL at PIT yet. Lines usually go up a few hours before first pitch or tip-off; check back closer to game time. See all of today’s free picks across the slate.

Injury Report

12 listed

JUST IN: Hunter Dobbins day-to-day → 15-Day IL (Elbow) · Blaze Jordan day-to-day → 10-Day IL (Ankle) · JJ Wetherholt day-to-day → 10-Day IL (Wrist) · Everson Pereira out → 10-Day IL (Hand) · Endy Rodriguez 10-day-il → 60-Day IL (Hip) · Braxton Ashcraft bereavement → 15-Day IL (Arm) · Esmerlyn Valdez day-to-day → 10-Day IL (Hamstring)

STL

Max Rajcic
Elbow·Since Jul 22
60-Day IL
Hunter Dobbins
Elbow·Since Aug 21
15-Day IL
Blaze Jordan
Ankle·Since Aug 27
10-Day IL
JJ Wetherholt
Wrist·Since Aug 29
10-Day IL
Everson Pereira
Hand·Since Aug 21
10-Day IL
Peter Strzelecki
Forearm·Since Aug 26
15-Day IL

PIT

Endy Rodriguez
Hip·Since Aug 13
60-Day IL
Mitch Keller
Arm·Since Aug 2
60-Day IL
Braxton Ashcraft
Arm·Since Sep 9
15-Day IL
Esmerlyn Valdez
Hamstring·Since Sep 11
10-Day IL
Kirby Yates
Shoulder·Since Sep 2
15-Day IL
Isaac Mattson
Hip·Since Sep 7
15-Day IL

Team Trends

St. Louis Cardinals

• St. Louis Cardinals 40-35 ATS at home, 53%
• St. Louis Cardinals 16-30 ATS as a favorite this season
• St. Louis Cardinals 65-36 ATS as an underdog
• The over has hit in 7 of the last 10

Season ATS: 82-68 ATS
L10 ATS: 6-4 L10 ATS
L5 ATS: 3-2 L5 ATS
Home ATS: 40-35 home ATS
Road ATS: 42-33 road ATS
As Fav: 16-30 ATS as favorite
As Dog: 65-36 ATS as dog
L10 O/U: 7-3 O/U
L10 SU: 5-5

Pittsburgh Pirates

• Pittsburgh Pirates 33-39 ATS at home this season
• Pittsburgh Pirates 34-42 ATS as a favorite this season
• Pittsburgh Pirates 38-33 ATS as an underdog
• The under has hit in 7 of the last 10

Season ATS: 73-77 ATS
L10 ATS: 6-4 L10 ATS
L5 ATS: 4-1 L5 ATS
Home ATS: 33-39 home ATS
Road ATS: 40-38 road ATS
As Fav: 34-42 ATS as favorite
As Dog: 38-33 ATS as dog
L10 O/U: 2-7-1 O/U
L10 SU: 7-3

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Head-to-Head

PIT 4-1 over STL (3-2 ATS)

Date	Matchup	Score	Winner
2026-08-30	PIT @ STL	5–4	PIT
2026-08-29	PIT @ STL	6–2	PIT
2026-08-29	PIT @ STL	1–4	STL
2026-05-21	PIT @ STL	6–2	PIT
2026-05-20	PIT @ STL	7–0	PIT

Picks, parlays, injuries, trends, and matchup context powered byDataStreak

The Final Word

Some games you watch for the result. Some you watch for the props. Tonight is both.

Cardinals vs Pirates FAQ

Where can I find free Cardinals vs Pirates picks for Tuesday, September 22, 2026?

Today's algorithmic plays didn't include Cardinals vs Pirates, but our full free MLB picks page covers every matchup that did clear the quality bar.

What's the prediction for Cardinals vs Pirates?

Our prediction is built from team form (records, recent results, win/loss streaks), live moneyline and spread odds across major US books, and DataStreak's algorithmic player-prop research. Every claim on this page is data-backed — no hot takes.

Are these Cardinals vs Pirates best bets really free?

Yes. Every prediction, pick, and parlay on this page is free, no signup, no paywall.

How is The Cover different from Covers, ATS, or pay-for-pick services?

Three things. (1) Free, full stop — every page, every day. (2) Picks are algorithmic with transparent quality bars (8+ game streak, 75%+ hit rate over 20 games), not opinion columns. (3) Modern UX: live odds, push notifications, comments, mobile-first PWA install.