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Lions vs Bills Prediction, Picks, Best Bets & Parlay

Free NFL prediction and picks for Thursday, September 17, 2026 · powered by DataStreak

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Detroit Lions

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Buffalo Bills

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Lions vs Bills Prediction

Not the marquee game on the board, not the worst one either. Picks make it more interesting than the stats sheet.

Two teams, one slate of props, and a model that's been right more than it's been wrong. The plays below earned their spot.

Lions vs Bills Picks

Books have not posted player props for DET at BUF yet. Lines usually go up a few hours before first pitch or tip-off; check back closer to game time. See all of today’s free picks across the slate.

Injury Report

19 listed

JUST IN: Isiah Pacheco ir → Injured Reserve (Back) · Brian Branch pup-p → PUP R (Achilles) · Kerby Joseph pup-p → PUP R (Knee) · Damone Clark ir → Injured Reserve (Undisclosed) · Giovanni Manu nfi-a → NFI R (Knee) · Kendrick Law injured-reserve → IR · Payton Turner ir → Injured Reserve (Back) · Christian Izien out → Questionable (Groin) · Derrick Moore active → Questionable (Hamstring) · Tyrell Shavers pup-p → PUP R (Knee - ACL) · Zane Durant ir-r → Injured Reserve (Undisclosed) · Dorian Strong out → NFI R (Neck) · Ty Johnson active → Questionable (Lower Leg) · Jude Bowry active → Questionable (Foot)

DET

Isiah Pacheco
Back
Injured Reserve
Brian Branch
Achilles
PUP R
Kerby Joseph
Knee
PUP R
Damone Clark
Undisclosed
Injured Reserve
Giovanni Manu
Knee
NFI R
Kendrick Law
IR
Payton Turner
Back
Injured Reserve
Christian Izien
Groin
Questionable
Derrick Moore
Hamstring
Questionable
Mekhi Wingo
Questionable

BUF

Tyrell Shavers
Knee - ACL
PUP R
Zane Durant
Undisclosed
Injured Reserve
Dorian Strong
Neck
NFI R
Phidarian Mathis
Suspension
Reserve Sus
Ty Johnson
Lower Leg
Questionable
Jude Bowry
Foot
Questionable
T.J. Sanders
Knee
Questionable
Jedrick Wills Jr.
Back
Questionable
Jordan Hancock
Quadriceps
Questionable

Team Trends

Detroit Lions

Season ATS: 0-0 ATS
L10 ATS: 0-0 L10 ATS
L5 ATS: 0-0 L5 ATS
Home ATS: 0-0 home ATS
Road ATS: 0-0 road ATS
As Fav: 0-0 ATS as favorite
As Dog: 0-0 ATS as dog
L10 O/U: 0-0 O/U
L10 SU: 4-6

Buffalo Bills

Season ATS: 0-0 ATS
L10 ATS: 0-0 L10 ATS
L5 ATS: 0-0 L5 ATS
Home ATS: 0-0 home ATS
Road ATS: 0-0 road ATS
As Fav: 0-0 ATS as favorite
As Dog: 0-0 ATS as dog
L10 O/U: 0-0 O/U
L10 SU: 7-3

Head-to-Head

BUF 2-0 over DET (1-1 ATS)

Date	Matchup	Score	Winner
2024-12-15	BUF @ DET	48–42	BUF
2022-11-24	BUF @ DET	28–25	BUF

Picks, parlays, injuries, trends, and matchup context powered byDataStreak

The Final Word

Numbers in, narrative out. The plays speak for themselves.

Lions vs Bills FAQ

Where can I find free Lions vs Bills picks for Thursday, September 17, 2026?

Today's algorithmic plays didn't include Lions vs Bills, but our full free NFL picks page covers every matchup that did clear the quality bar.

What's the prediction for Lions vs Bills?

Our prediction is built from team form (records, recent results, win/loss streaks), live moneyline and spread odds across major US books, and DataStreak's algorithmic player-prop research. Every claim on this page is data-backed — no hot takes.

Are these Lions vs Bills best bets really free?

Yes. Every prediction, pick, and parlay on this page is free, no signup, no paywall.

How is The Cover different from Covers, ATS, or pay-for-pick services?

Three things. (1) Free, full stop — every page, every day. (2) Picks are algorithmic with transparent quality bars (8+ game streak, 75%+ hit rate over 20 games), not opinion columns. (3) Modern UX: live odds, push notifications, comments, mobile-first PWA install.